I’m Lucas Richert, an expert in the history of pharmaceuticals, the historical director for the American Institute of the History of Pharmacy at UW-Madison, and the author of “Break On Through.” AMA!

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Hey Lucas! Thanks for the AMA. What do you think about so-called “tardive dysphoria”, or treatment resistant depression being created by long term exposure to antidepressant therapy? I’ve read a few papers on this, but I haven’t heard an expert opinion in years. The last opinion I heard was essentially “gosh I hope that’s not a thing, but maybe?” which is… not exactly encouraging. And for those folks on anti-depressants, please don’t take this question as a reason to hop off of them. Talk to your doctor. They can and have helped millions of folks in the world!


Hi Lucas Are pharmaceutical companies as evil as the media headlines make them out to be? What are some realities of the industry that are often overlooked in media critiques of pharmaceuticals? What can be improved? Thank you


What can you explain about the move to close mental institutions in the US? It seems like now there is a need for them, because most serious patients are just shipped around hospitals or end up in jail instead of long-term care. Though I understand the institutions were problematic, it seems to me they were better than the non-system we have now. Is there anyone pushing to reopen them?


Hello, I have been on antipsychotis and mood stablizers since I was 13 years old, now 18 years later I am now classified med resistant and have many physical medical problems some caused by long term use of those medications. My question is how many studies if any talk about the long term affects of heavy doses of these medications when given to teens and women? I also wonder how you feel about the practice of advertising medications like latuda and vraylar to the general public?


How rapidly has the use of pharmaceuticals increased on a per capita basis since 1997, when the FDA allowed widespread use of television advertising to sell drugs? How does the prevalence of pharmaceutical drug use differ in countries that do not allow advertising? Finally, do you think per capita use will ever decrease in the US?