Researchers have identified a drug that works against depression by a completely different mechanism than existing treatments. Ezogabine, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression.

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This particular drug was discontinued because it had nasty side effects like turning people’s skin blue. This is because it opens KCNQ2/3/4/5, making it too broad acting. The university of Pittsburgh is developing a drug called RL81 which opens only KCNQ2/3


Anhedonia doesn’t get touched by SSRIs for me. This would be life changing for millions


I’d deal with my anhedonia but what’s the point?


What is it with anti-convulsants and their links to depression and stability? I’m mainly asking rhetorically but if someone actually knows the answer to this I’d love to hear it.


Seems dangerous “The most common adverse effects were drowsiness, dizziness, tinnitus and vertigo, confusion, and slurred speech.Less common side effects included tremor, memory loss, gait disturbances, and double vision In 2013 FDA warned the public that, Potiga (ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina. FDA does not currently know if these changes are reversible. FDA is working with the manufacturer to gather and evaluate all available information to better understand these events. FDA will update the public when more information is available. Psychiatric symptoms and difficulty urinating have also been reported, with most cases occurring in the first 2 months of treatment.”