The epsilon variant of SARS-CoV-2, first detected California, carries three spike protein mutations that confer resistance to neutralizing antibodies generated by mRNA vaccines or by SARS-CoV-2 infection, according to new research in Science.

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This in vitro study doesn’t seem to reliably predict outcomes in vivo. If it did, we would be seeing mRNA-vaccinated people coming down with the epsilon variant, like those vaccinated with the Chinese vaccine are coming down with the Delta variant. The Chinese vaccine is useless with Delta variant infections spreading like wildfire in sinovax administered countries, while the mRNA vaccine seems to be providing solid protection.


Abstract: A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based mRNA vaccine or convalescent individuals exhibited neutralizing titers, which were reduced 2-3.5 fold against the B.1.427/B.1.429 variant relative to wildtype pseudoviruses. The L452R mutation reduced neutralizing activity of 14 out of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 out of 10 NTD-specific mAbs since the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and formation of a new disulphide bond, as revealed by mass spectrometry and structural studies.


Germany is now doing what they call cross-vaccination. One shot of a vector vaccine and after 4-8 weeks a mRNA shot. Will this help with Epsilon?


Serious question: do people still care about the virus? If so why? Everyone that wants a vaccine has been able to get one by this point and those that don’t will live with the risk of contracting the virus. It just seems to me that the risk of the virus is like “irrelevant” now idk. I’m asking a serious question so don’t attack me as I bet many are chomping at the bit to do after reading that.