Alcohol consumption is affected by a protein linked to the circadian rhythm. The presence of the Bmal1 gene in a part of the forebrain has opposite effects on ethanol intake for males and females. Addiction treatment specialists could ultimately use this knowledge to develop sex-based treatment.

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Sex based treatment you say ( ͝° ͜ʖ͡°)


I’m le dumb can we get a TL;DR


That took a different route than I expected.


This kind of makes sense. Circadian clock controld pregnalone synthesis. Pregnalone levels determine allopregnanalone levels. Alcohol raises ALLO. Men and women have different responses to allopregnanalone. ALLO levels influence ethanol intake. If that’s the case we would expect this gene to be associated with disorders related to ALLO like PMDD, ASD, and ADHD. Edit: A little googling shows that is the case. Neat.


I wonder how people on differing hormones fit in. If I had to guess, I’d bet that after a few years of medical hormone therapy, the individual would react much the same as the gender they’re transitioning to. But then, I don’t know much.