Mystery of why humans die around 80 may finally be solved

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Watch us be the last generation to fucking DIE. Goddamn millennials got screwed


I know I am in the minority on this but I really believe we better figure out how to make better people before we start massively extending lifespans. If Mitch McConnell can rule for another 75 years you havent fixed anything. Extended lifespans for humans in their current state is simply extending misery, stupidity and stagnation. Edit- Little too late to mention it but I was referring to genetic engineering when I said ‘make better people’. That is why I thought I was in the minority.


To understand the paper better:They looked at a specific group of cells in the intestine. The cells of this group constantly die and are replaced by a single stem cell. Therefore, they will have pretty much all the mutations the stem cell has.They didn’t find that a human wil sustain 3200 mutations over their lifetime. The 3200 mutations are the number that they found on average per cell. So more correctly: Certain intestinal stem cells seem to sustain 3200 mutations over a human lifetime. More importantly: Only 31 mutations were observed in genetic regions that actually do stuff (code for proteins). However, genes can actually mutate without changing the resulting protein at all. Also, proteins can change without losing their function to a clinically relevant degree. So whether this has any health impact at all isn’t certain. My comment: The paper does not in any way show that somatic mutations are “the” cause for aging. They conclude as much themselves: “Jointly, these models predict ageing to be multifactorial, with multiple forms of molecular and cellular damage contributing to organismal ageing owing to evolutionary limits to selection acting on the rates of these processes.”Humans are a set of many systems. DNA repair, cancer suppression, immune system, blood vessels, and so on. All of these systems have been shaped by evolution to work only as well as needed to produce viable offspring. Any more is usually a waste of resources.This means that many of them will fail rather simultaneously. That’s why the risk of so many completely different diseases simultaneously rises so dramatically in the decades approaching roughly 80.All of these are different aspects to aging. All of them need therapeutic responses. Not dying from cancer at 80 still leaves you open from a heart attack, an infection, a stroke, etc. in the same year.


Is it because we’re just tired? Because I’m 40 and already tired. Doubling that, yeah, I’d kind of just want to lay down and be done.


Is there anything new actually being reported by this study? I remember when CRISPR and Cas9 first were announced, people were immediately linking it to possible age extension down the road due to us being able to clean up damaged DNA. Obviously a lot of other advancements are required before that would be possible, but if people were accurately assessing the possibilities at the time that means the reason was already widely known.